Funded by the Institute for Scientific Information on Coffee (ISIC) — an industry body — which is a notable conflict of interest the authors disclose but don't extensively discuss
After habitually consuming caffeine (not in coffee form) daily, usually multiple times a day, for more than a decade, a horrible mental health incident happened to me that forced me to stop it for a while. Afterwards I didn't resume the habit, and so I no longer have a tolerance.
This has let me evaluate what caffeine does with fresh eyes, so to say, because I can now consume it occasionally while having many non-caffeinated days to compare to. It's a profoundly psychoactive substance and does a lot of things to cognition. I guess I have decided I don't enjoy how it feels, having previously been dependent on it.
Agree, I drink it a lot and then stop drinking it at least once a year for a few weeks, and for sure it's a different mode of mind, but can't really qualify it besides that I remember my thinking being softer, calmer and perhaps even "more correct" without coffee.
(But I never had any mental-health incidents, and I drink a lot of it, more than all people that I personally know.)
I've had the same experience. Caffeine is super addicting, the ritual & habits surrounding it is a potent pull. For myself, it makes me erratic, impulsive, more reactive and agitated. One cup a day puts me on edge, makes me sweat more, makes me more intolerant, makes everything feel too slow. It such a sneaky drug and it can really get under your skin without you realizing how much it changes you.
The overwhelming majority of the enjoyable coffee experiences are caffeinated. While there is good decaf out there it's not the norm, specially in smaller markets.
I’m super interested in this sort of study! However, it looks like n=62 here, which I think weakens the results —they’re probably just useful as suggestions of possible effects. Also, any food is expected to have similar effects on the microbiome. They didn’t test caffeine in isolation. In some ways that’s better (I don’t consume caffeine in isolation), but in some ways that’s less useful (it’s possible you get similar results from many random vegetables)
But they did test both caffeinated and uncaffeinated coffee, and found the same effects in both, indicating that the effect is caused by something in coffee other than the caffeine
Typical extraction yield is 18-20%. For a 20g dose that's 4g of material consumed, or about 30 individual beans.
I wonder if you could find similar effects with 4g or broccoli sprouts, or garlic, or ginger, or cumin seed, shiitake mushroom, seaweed, soursop leaf, or...
I must be weird, but coffee (or caffeine) doesn’t really “wake me up” in the mornings and I could drink it in the night and still sleep well. Because of that I don’t drink coffee; I prefer tea
tea also has caffeine, although in smaller quantities. Maybe you mean that you don't care so you go by taste, just specifying because there's a common misconception about tea not having caffeine.
all tea has caffeine unless it's decaf. some things that aren't tea are called tea casually, but they aren't tea, for instance peppermint "tea" is not tea. by the same logic that one would call peppermint a tea, one would have to call coffee a tea. and beef broth.
What's cool is this effect exists even in decaf coffee, as someone who primarily drinks decaf black, for flavor and for a good night's rest as I'm sensitive to caffeine.
What kind of decaf coffee do you drink? There are differences between the cheap chemical Methylene way to create decaf coffee and the expensive co2 way to get rid of the caffeine.
Is that methylene way even legal? It basically uses petroleum fuel in the process right? I assume it was outlawed a long time ago but that might be extreme naievete for US regulatory capability...
https://www.thedecafproject.com/ (Dec 2024) let you order matching swiss water, CO₂, and Ethyl Acetate (sugar cane byproduct) decaffeinated coffee from the same batches of beans. The EPA banned methylene chloride earlier in that year, but because of toxicity to workers, not because of risk from the resulting coffee itself (and it looks like the FDA didn't ban it.) So I guess you couldn't make decaf with it in the US but you could probably still import and sell it?
It would have been interesting to see if there was any difference relating to CYP1A2 (Cytochrome P450 1A2), the fast metabolizers and the slow metabolizers.
I have not much followed the science of gut microbiome and psychology. Is this really going where this article is pointing? That we can tease out causation in foods and habits via gut microbiome towards behavior and psychology? Pretty rad.
There's a decent amount of research going into the hormones that our GI biome produce and how it affects us. Our body has a few different biomes and they all seem to play somewhat important roles.
Studies seem to indicate that coffee is at least as healthy, if not healthier than tea, and I have not heard this about caffeine specifically (aka the same effects coming from pills or energy drinks).
One fun fact: we still haven’t figured out why coffee makes us poop. We’ve studied every chemical in there and can’t seem to find a link, but the association is uh… well-known.
The only good thing that keeps me from collapsing into a state of limbo is coffee and now, even that's bad (seems more like a mixed bag, but still)? Sigh.
Maybe I have some neurological issue or something but whenever I quit coffee I find it extremely difficult to maintain any kind of motivation to sit in an open plan office and code. Coffee makes me a worker bee, I can understand why employers give it away for free.
Yeah, exactly. I can totally relate to this. I have actually monitored my productivity on an excel sheet and the days with coffee win by a large margin. I am not sure if it's withdrawal symptoms on the days without, though.
"These findings reveal previously unrecognised effects of coffee on the microbiota–gut–brain axis, suggesting that microbiome profiles could potentially predict coffee consumption patterns", or, perhaps, just ask the patient?
If you can predict someone's coffee intake based on testing of their microbiome then you've proven that coffee intake has predictable effects on the microbiome.
The important part isn't predicting coffee use, it's just the proof that there's you can predict and perhaps control in the opposite direction leading to more research.
Behaviourally, coffee drinkers exhibited greater impulsivity and emotional reactivity, whereas non-coffee drinkers demonstrated better memory performance.
Who said anything about big coffee? These guys might be a secret, anti-coffee organisation. /s
This has let me evaluate what caffeine does with fresh eyes, so to say, because I can now consume it occasionally while having many non-caffeinated days to compare to. It's a profoundly psychoactive substance and does a lot of things to cognition. I guess I have decided I don't enjoy how it feels, having previously been dependent on it.
(But I never had any mental-health incidents, and I drink a lot of it, more than all people that I personally know.)
3-5 is moderate? To me, 3 is already high.
Also, sample size is pretty low and they're all Irish.
https://rarehistoricalphotos.com/nasa-spiders-drugs-experime...
But they did test both caffeinated and uncaffeinated coffee, and found the same effects in both, indicating that the effect is caused by something in coffee other than the caffeine
I wonder if you could find similar effects with 4g or broccoli sprouts, or garlic, or ginger, or cumin seed, shiitake mushroom, seaweed, soursop leaf, or...
Falling asleep after a can of energy drink.
https://cleanlabelproject.org/wp-content/uploads/CLP-Decaf-C...
I would probably drop coffee it was proven to have negative effects on memory.
you don't remember why, do you?
This sounds interesting. I've never really considered the constituents of coffee other than caffeine and what unique effects they may bring.
I wonder if I would experience behavioral effects if I replaced my coffee intake with caffeinated non-coffee drinks or pills?
One fun fact: we still haven’t figured out why coffee makes us poop. We’ve studied every chemical in there and can’t seem to find a link, but the association is uh… well-known.
That seems to vary wildly between individuals. It doesn't have that effect on me.
So, the coffee stays for now.
If you can predict someone's coffee intake based on testing of their microbiome then you've proven that coffee intake has predictable effects on the microbiome.
The important part isn't predicting coffee use, it's just the proof that there's you can predict and perhaps control in the opposite direction leading to more research.